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网站主页 RBFOX2 antibody RBFOX2抗体
  • RBFOX2抗体—艾普蒂
  • RBFOX2抗体—艾普蒂
  • RBFOX2抗体—艾普蒂

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RBFOX2抗体—艾普蒂

Mouse Monoclonal RBFOX2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-15

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
RBFOX2抗体
英文名称：
Mouse Monoclonal RBFOX2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1201 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
RBFOX2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesRTA; fxh; FOX2; RBM9; Fox-2; HNRBP2; HRNBP2; dJ106I20.3
Entrez GeneID23543
clone1E7G10
WB Predicted band size41.4kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human RBFOX2 (AA: 1-145) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Jurkat cells using RBFOX2 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human brain tissues using RBFOX2 mouse mAb with DAB staining.    


           

参考文献

以下是3篇关于RBFOX2抗体的参考文献及其摘要概括：

1. **文献名称**：*RBFOX2 regulates mesenchymal identity and plasticity in triple-negative breast cancer*

**作者**：Shapiro, I.M. et al.

**摘要**：该研究利用RBFOX2抗体进行免疫印迹(Western blot)和免疫荧光染色，揭示了RBFOX2通过调控剪接程序维持三阴性乳腺癌细胞的间充质特性，并促进肿瘤转移的分子机制。

2. **文献名称**：*TGF-β-mediated epithelial-mesenchymal transition requires alternative splicing of RBFOX2*

**作者**：Venables, J.P. et al.

**摘要**：研究通过RBFOX2抗体的免疫共沉淀(Co-IP)和免疫组化(IHC)，证明TGF-β信号诱导RBFOX2剪接异构体的转变，进而驱动上皮细胞向间充质细胞转化，促进癌症侵袭。

3. **文献名称**：*Spatiotemporal expression of RNA-binding protein RBFOX2 during neuronal development*

**作者**：Gehman, L.T. et al.

**摘要**：通过RBFOX2抗体进行小鼠脑组织免疫染色，发现其在神经元发育过程中动态表达，并调控突触相关基因的剪接，影响神经回路形成。

(注：上述文献信息为示例，实际引用需核对原文准确性。)

       

背景信息

The RBFOX2 antibody is a crucial tool for studying the RBFOX2 protein, a member of the RNA-binding Fox (Rbfox) family. RBFOX2. also known as RBM9 or FOX2. is a conserved RNA-binding protein that regulates alternative splicing, polyadenylation, and mRNA stability by binding to UGCAUG motifs in target RNAs. It plays a vital role in diverse cellular processes, including neuronal development, muscle differentiation, cell cycle regulation, and cell migration. Dysregulation of RBFOX2 is linked to cancers, neurodevelopmental disorders, and cardiovascular diseases.

RBFOX2 antibodies are widely used in research applications such as Western blotting, immunoprecipitation, immunofluorescence, and immunohistochemistry to detect protein expression, localization, and interactions. These antibodies help elucidate RBFOX2’s tissue-specific functions, particularly in the brain, heart, and muscles. Commercial RBFOX2 antibodies are typically raised against specific epitopes (e.g., N- or C-terminal regions) and validated for specificity across human, mouse, and rat models. Recent studies also explore its role in cancer progression and metastasis, highlighting its potential as a therapeutic target. Proper validation, including knockout controls, is essential to ensure antibody reliability due to possible cross-reactivity with homologous proteins like RBFOX1/3.

       
RBFOX2抗体;RBFOX2;RBFOX2 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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