SATB2抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using SATB2 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using SATB2 mouse mAb with DAB staining.    

  
  

SATB2 (Special AT-rich sequence-binding protein 2) is a nuclear matrix-associated transcription factor that plays critical roles in transcriptional regulation, chromatin remodeling, and epigenetic modifications. It is primarily expressed during embryonic development, particularly in tissues derived from the neural crest, such as the craniofacial skeleton and the central nervous system. SATB2 is essential for osteoblast differentiation, palate formation, and neuronal development, with mutations linked to human syndromes featuring intellectual disability, craniofacial abnormalities, and dental defects.

In diagnostic pathology, SATB2 antibodies are widely used as immunohistochemical markers. SATB2 is highly specific for tissues of osteoblastic and neuronal origin, making it valuable in identifying osteosarcomas, colorectal adenocarcinomas, and certain neural tumors. Its expression in colorectal cancer (≈85-90% positivity) helps distinguish it from other gastrointestinal or gynecological malignancies. Additionally, SATB2 is employed to study neurodevelopmental disorders and craniofacial malformations. As a research tool, SATB2 antibodies aid in investigating gene regulatory networks involving SATB2’s binding to nuclear matrix attachment regions (MARs), which organize chromatin architecture to modulate gene expression. Its dual role in both developmental biology and cancer continues to drive interdisciplinary research interest.