EDA2R抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of MOLT4 cells using EDA2R mouse mAb (green) and negative control (red).    

  
  

The EDA2R (ectodysplasin A2 receptor) antibody is a crucial tool in studying the EDA-A2/EDA2R signaling pathway, which plays a pivotal role in ectodermal development. EDA2R, also known as XEDAR, is a tumor necrosis factor receptor (TNFR) superfamily member encoded on the X chromosome. It specifically binds to ectodysplasin-A2 (EDA-A2), a splice variant of the EDA protein produced by the *ED1* gene. This ligand-receptor interaction activates NF-κB and other downstream pathways, regulating the formation of ectodermal structures such as hair, teeth, sweat glands, and skin appendages during embryogenesis.

Mutations in *EDA* or *EDA2R* are linked to X-linked hypohidrotic ectodermal dysplasia (XLHED), a disorder characterized by impaired development of ectodermal tissues. EDA2R antibodies are widely used in research to detect receptor expression, map signaling mechanisms, and explore therapeutic strategies. For example, recombinant EDA-A2 protein or agonist antibodies targeting EDA2R are being investigated to rescue developmental defects in XLHED models. Additionally, these antibodies aid in diagnosing ectodermal dysplasia subtypes and studying receptor-ligand dynamics in cancers or inflammatory conditions where EDA2R may be dysregulated. Their applications span immunohistochemistry, Western blotting, and functional assays, contributing to both basic research and translational medicine in developmental biology and genetic disorders.