CD243抗体—艾普蒂 新品

+ +

•  

   

     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

•  

   

     Flow cytometric analysis of HL-60 cells using CD243 mouse mAb (green) and negative control (red).    

  
  

CD243. also known as P-glycoprotein (P-gp) or multidrug resistance protein 1 (MDR1), is a transmembrane efflux pump encoded by the *ABCB1* gene. It belongs to the ATP-binding cassette (ABC) transporter superfamily and plays a critical role in exporting xenobiotics, drugs, and toxins out of cells, contributing to multidrug resistance (MDR) in cancers. Overexpression of CD243 in tumor cells reduces intracellular drug accumulation, diminishing chemotherapy efficacy. This protein is also expressed in normal tissues (e.g., intestines, liver, blood-brain barrier) to protect against toxins and regulate drug absorption/metabolism.

CD243 antibodies are essential tools for detecting and quantifying P-gp expression in research and diagnostics. They are widely used in techniques like flow cytometry, immunohistochemistry, and Western blotting to study MDR mechanisms, evaluate cancer prognosis, or investigate drug distribution in pharmacokinetics. Monoclonal antibodies (e.g., UIC2. MRK16) target specific extracellular epitopes, enabling functional studies, while polyclonal antibodies may offer broader epitope recognition. Challenges include ensuring antibody specificity due to homology among ABC transporters. Recent therapeutic strategies explore blocking CD243 to reverse drug resistance or leveraging its expression for targeted drug delivery.