CD203C抗体—艾普蒂 新品

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of HL-60 cells using CD203C mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human renal cancer tissues using CD203C mouse mAb with DAB staining.    

  
  

CD203c, also known as ectonucleotide pyrophosphatase/phosphodiesterase 3 (ENPP3), is a transmembrane glycoprotein belonging to the ectoenzyme family. It exhibits enzymatic activity, hydrolyzing extracellular nucleotides like ATP and NAD+, and is involved in purinergic signaling pathways. Primarily expressed on the surface of basophils and mast cells, CD203c serves as a dynamic activation marker for these cells, with its surface expression upregulated upon IgE-mediated stimulation or exposure to allergens.

The CD203c antibody specifically targets this glycoprotein, enabling its detection and quantification in clinical and research settings. Its application is particularly valuable in allergy diagnostics. Flow cytometry using CD203c antibodies allows precise identification of activated basophils in peripheral blood, offering a functional approach to assess individual sensitization patterns. This method (basophil activation test) demonstrates higher sensitivity and specificity compared to traditional IgE measurements or skin prick tests, especially for drug allergies and complex food allergies.

Moreover, CD203c antibodies help differentiate basophils from other granulocytes due to its lineage-specific expression. While CD63 is another basophil activation marker, CD203c shows earlier and more sustained upregulation post-activation, making it advantageous for clinical testing. Ongoing research explores its potential in monitoring immunotherapy efficacy and understanding mast cell-related disorders.