P2RY2抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using P2RY2 mouse mAb (green) and negative control (red).    

  
  

P2RY2 (P2Y2 receptor) is a G protein-coupled receptor (GPCR) that belongs to the purinergic receptor family, which responds to extracellular nucleotides like ATP and UTP. It plays a critical role in mediating cellular responses to tissue injury, inflammation, and mechanical stress by regulating processes such as ion transport, mucus secretion, cell proliferation, and immune cell activation. P2RY2 is widely expressed in epithelial, endothelial, immune, and neural tissues, highlighting its involvement in diverse physiological and pathological pathways. Dysregulation of P2RY2 signaling has been implicated in diseases including cystic fibrosis, cancer, chronic inflammation, and fibrosis, making it a potential therapeutic target.

Antibodies targeting P2RY2 are essential tools for studying its expression, localization, and function. They enable detection of receptor levels in tissues or cell lines via techniques like Western blot, immunohistochemistry, and flow cytometry. Additionally, P2RY2 antibodies are used to investigate receptor activation mechanisms, ligand interactions, and downstream signaling cascades. In therapeutic research, neutralizing antibodies or antibody-based inhibitors are explored to block P2RY2 activity in conditions like inflammatory disorders or tumor progression. Despite progress, challenges remain in understanding tissue-specific signaling nuances and developing clinically viable antibody therapies. Overall, P2RY2 antibodies bridge basic research and translational applications, offering insights into receptor biology and disease modulation.