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  • CD66A抗体—艾普蒂
  • CD66A抗体—艾普蒂
  • CD66A抗体—艾普蒂

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CD66A抗体—艾普蒂

Mouse Monoclonal CD66A Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-15

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
CD66A抗体
英文名称：
Mouse Monoclonal CD66A Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1071 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CD66A

验证与应用

应用及物种
WB1/500 - 1/2000 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesCEACAM1; BGP; BGP1; BGPI
Entrez GeneID634
clone7B9G3
WB Predicted band size57.6kDa
Host/IsotypeMouse IgG2b
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD66A (AA: extra 65-201) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Western blot analysis using CD66A mouse mAb against HepG2 (1), SK-MES-1 (2), Hela (3), and A549 (4) cell lysate.    


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       Flow cytometric analysis of Hela cells using CD66A mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human lung cancer tissues using CD66A mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CD66A mouse mAb with DAB staining.    


           

参考文献

以下是关于CD66A(CEACAM1)抗体的3篇参考文献，按研究主题分类简要概括：

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1. **文献名称**: *CEACAM1 regulates TIM-3-mediated tolerance and exhaustion*

**作者**: Huang YH, et al.

**摘要**: 研究揭示了CEACAM1(CD66a)与TIM-3受体相互作用，负向调控T细胞活性，影响抗肿瘤免疫反应。文中通过抗体阻断实验证实了其在免疫检查点通路中的作用。

2. **文献名称**: *Neisseria gonorrhoeae exploits CEACAM1 for infection of human cervical epithelia*

**作者**: Muenzner P, et al.

**摘要**: 探讨了CEACAM1作为致病菌(如淋球菌)的宿主受体机制，利用CD66a抗体阻断实验证明其介导细菌黏附与侵袭上皮细胞的过程。

3. **文献名称**: *CEACAM1 in apoptosis and epithelial integrity*

**作者**: Gray-Owen SD, et al.

**摘要**: 分析了CEACAM1在结肠癌细胞凋亡和细胞间连接中的作用，通过特异性抗体标记揭示了其参与肿瘤微环境调控的分子机制。

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以上文献均涉及CD66A/CEACAM1抗体的应用，涵盖免疫调控、病原体感染和肿瘤研究等领域。如需具体年份或期刊信息，可进一步补充关键词检索。

       

背景信息

CD66a antibody targets the CD66a antigen, also known as CEACAM1 (Carcinoembryonic Antigen-Related Cell Adhesion Molecule 1), a member of the CEACAM family. CEACAM1 is a transmembrane glycoprotein involved in cell adhesion, signaling, and immune regulation. It contains an N-terminal immunoglobulin (Ig)-like variable (IgV) domain, followed by multiple Ig-like constant (IgC2) domains, a transmembrane region, and a cytoplasmic tail with varying lengths due to alternative splicing. This structural diversity enables CEACAM1 to mediate both homophilic and heterophilic interactions, influencing processes like tumor suppression, angiogenesis, and immune cell modulation.

CD66a/CEACAM1 is expressed on epithelial, endothelial, and immune cells (e.g., T cells, neutrophils). It acts as a co-inhibitory receptor in T cells, dampening activation and cytokine production, which is critical in autoimmune diseases and cancer immune evasion. Its dysregulation is linked to tumor progression, chronic inflammation, and infections (e.g., *Neisseria* adhesion). CD66a antibodies are widely used in research to study CEACAM1's roles in immune tolerance, pathogen-host interactions, and cancer biology. They are employed in techniques like flow cytometry, immunohistochemistry, and functional blocking assays. Commercial CD66a antibodies are typically monoclonal, generated in mice or rats, and validated for specificity against recombinant or native CEACAM1 isoforms.

       
CD66A抗体;CD66A;CD66A Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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