CD63抗体—艾普蒂

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     Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    

  
  

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     Flow cytometric analysis of Hela cells using CD63 mouse mAb (green) and negative control (red).    

  
  

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     Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CD63 mouse mAb with DAB staining.    

  
  

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     Immunohistochemical analysis of paraffin-embedded human rectum cancer tissues using CD63 mouse mAb with DAB staining.    

  
  

CD63 antibody is a tool used to detect CD63. a transmembrane protein belonging to the tetraspanin family. CD63. also known as lysosomal-associated membrane protein 3 (LAMP-3), is widely expressed in various cell types and is enriched in endosomal/lysosomal compartments and exosomes. It plays roles in cell adhesion, migration, intracellular trafficking, and signal transduction. As a marker of exosomes, CD63 is frequently employed in extracellular vesicle research to characterize these nanovesicles involved in intercellular communication, cancer progression, and immune regulation.

CD63 antibodies are crucial for identifying exosomes via techniques like flow cytometry, Western blotting, or immunofluorescence. They also aid in studying CD63's interaction with integrins, receptors, and other tetraspanins in membrane microdomains. Dysregulation of CD63 is linked to cancer metastasis, neurodegenerative diseases, and platelet activation. In diagnostics, CD63 antibodies may help profile disease-specific exosomes. Therapeutically, CD63 is explored for targeted drug delivery due to its exosomal surface presence.

Species cross-reactivity (human, mouse, rat) and epitope specificity vary among antibody clones, requiring validation for experimental contexts. Despite its utility, CD63's heterogeneous distribution across cell types and vesicles underscores the need for complementary markers in research.