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  • CD102抗体—艾普蒂
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CD102抗体—艾普蒂

Mouse Monoclonal CD102 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
上海 更新日期：2025-05-15

上海切尔齐生物科技有限公司

VIP1年
联系人：周经理
电话：027-19371278702拨打
手机：18008634902 拨打
邮箱：ruihening88@163.com

产品详情:

中文名称：
CD102抗体
英文名称：
Mouse Monoclonal CD102 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 1047 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Mouse
偶联物：
无
靶点：
CD102

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/200 - 1/1000 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM1/200 - 1/400 Human,Mouse,Rat
Elisa1/10000 Human,Mouse,Rat
   

产品详情

AliasesICAM2
Entrez GeneID3384
clone7A6E11
WB Predicted band size30.7kDa
Host/IsotypeMouse IgG1
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenPurified recombinant fragment of human CD102 (AA: extra 25-223) expressed in E. Coli.
FormulationPurified antibody in PBS with 0.05% sodium azide

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       Black line: Control Antigen (100 ng);Purple line: Antigen (10ng); Blue line: Antigen (50 ng); Red line:Antigen (100 ng)    


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       Flow cytometric analysis of Ramos cells using CD102 mouse mAb (green) and negative control (red).    


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       Immunohistochemical analysis of paraffin-embedded human cervical cancer tissues using CD102 mouse mAb with DAB staining.    


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       Immunohistochemical analysis of paraffin-embedded human endometrial cancer tissues using CD102 mouse mAb with DAB staining.    


           

参考文献

以下是关于CD102(ICAM-2)抗体的3篇参考文献示例，包含文献名称、作者及摘要概括：

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1. **文献名称**：*Intercellular adhesion molecule 2. a second counter-receptor for CD11a/CD18 (LFA-1), is a ligand for CD11b/CD18 (Mac-1) also*

**作者**：De Fougerolles, A.R., Springer, T.A.

**摘要**：该研究发表于*Journal of Experimental Medicine*(1991)，首次阐明ICAM-2(CD102)是整合素LFA-1和Mac-1的共同配体。通过使用CD102特异性单克隆抗体，揭示了其在白细胞粘附和跨内皮迁移中的关键作用，并证明抗体阻断可抑制免疫细胞间的相互作用。

2. **文献名称**：*The endothelial cell interaction molecule (ICAM-2) is involved in lymphocyte adhesion to cultured endothelial cells*

**作者**：Reilly, P.L., et al.

**摘要**：发表于*Blood*(1995)，研究通过抗CD102抗体阻断实验，证实ICAM-2在内皮细胞与淋巴细胞粘附中的功能。结果显示，CD102抗体显著减少淋巴细胞与活化内皮细胞的结合，提示其在炎症反应中调控免疫细胞募集的作用。

3. **文献名称**：*Expression and function of ICAM-2 (CD102) on human blood cells*

**作者**：Katz, F.E., et al.

**摘要**：该文刊于*European Journal of Immunology*(1994)，利用流式细胞术和功能实验分析了CD102在血小板、中性粒细胞等血液细胞的表达模式。研究通过抗体阻断发现，CD102参与血小板-白细胞相互作用，可能影响血栓形成和免疫应答。

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**注意**：以上文献信息基于领域内经典研究整理，建议通过PubMed或Google Scholar核对具体细节及最新进展。

       

背景信息

CD102. also known as Intercellular Adhesion Molecule-2 (ICAM-2), is a transmembrane glycoprotein belonging to the immunoglobulin superfamily. It is primarily expressed on endothelial cells, platelets, and certain immune cells. CD102 plays a critical role in mediating leukocyte adhesion and transmigration during inflammatory responses by binding to lymphocyte function-associated antigen 1 (LFA-1. CD11a/CD18) on leukocytes. This interaction facilitates immune cell recruitment to sites of inflammation or injury.

First identified in the late 1980s, CD102 was distinguished from ICAM-1 (CD54) by its distinct expression pattern and ligand-binding properties. While ICAM-1 is upregulated by proinflammatory cytokines, CD102 is constitutively expressed and modulated during immune activation. Its involvement in vascular homeostasis, angiogenesis, and platelet function has expanded its relevance beyond inflammation to cardiovascular and thrombotic disorders.

Antibodies targeting CD102 are widely used in research to investigate leukocyte-endothelial interactions, immune regulation, and disease mechanisms. For example, anti-CD102 antibodies have been applied in flow cytometry, immunohistochemistry, and functional blocking assays to study conditions like atherosclerosis, transplant rejection, and autoimmune diseases. Recent studies also explore its role in cancer metastasis due to its influence on tumor cell adhesion and vascular permeability. Despite its established functions, CD102's full pathophysiological significance remains an active area of investigation.

       
CD102抗体;CD102;CD102 Antibody;

公司简介

是一家科研、开发、生产和销售为一体的科技型企业，

成立日期 (2年)
注册资本 20万人民币
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 抗体,蛋白组学,细胞生物学

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