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KRT7抗体

Rabbit Polyclonal KRT7 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-15

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
KRT7抗体
英文名称：
Rabbit Polyclonal KRT7 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6660 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
KRT7

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/5000-1/10000 Human,Mouse,Rat
   

产品详情

AliasesK7; CK7; SCL; K2C7
WB Predicted band size51 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman
ImmunogenSynthetic peptide of human KRT7
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell lysate, Primary antibody: P12452(KRT7 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 seconds    


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       The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12452(KRT7 Antibody) at dilution 1/20. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12452(KRT7 Antibody) at dilution 1/20. (Original magnification: ×200)    


           

参考文献

以下是关于KRT7抗体的3-4篇参考文献的简要总结(文献标题、作者及摘要内容)：

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1. **标题**: *"The catalog of human cytokeratins: patterns of expression in normal epithelia, tumors, and cultured cells"*

**作者**: Moll R, Franke WW, Schiller DL, et al.

**摘要**: 该研究系统分类了人类细胞角蛋白(包括KRT7)，描述了其在正常上皮、肿瘤及培养细胞中的表达模式。KRT7在腺上皮和移行上皮中高表达，而在鳞状上皮中通常缺失，这为后续肿瘤分型提供了重要依据。

2. **标题**: *"Immunohistochemistry for diagnosis of metastatic carcinomas of unknown primary origin"*

**作者**: Chu P, Weiss LM.

**摘要**: 文章讨论了KRT7抗体在鉴别转移性癌原发部位中的应用，指出KRT7常与KRT20联合使用。例如，KRT7+/KRT20-可能提示肺或乳腺来源，而KRT7-/KRT20+则常见于结直肠癌，为临床病理诊断提供参考。

3. **标题**: *"The utility of cytokeratin 7 and 20 immunohistochemistry in the differential diagnosis of primary and metastatic liver carcinomas"*

**作者**: Bass BC, Parwani AV, Ali SZ.

**摘要**: 研究通过免疫组化分析肝肿瘤，发现KRT7在胆管癌中高表达，而在肝细胞癌中多为阴性，表明KRT7抗体有助于区分这两种肝脏原发肿瘤及转移性腺癌。

4. **标题**: *"Cytokeratin 7 and cytokeratin 20 expression in epithelial neoplasms: a survey of 435 cases"*

**作者**: Ramakers CR, van de Molengraft FJ, van Bokhoven A, et al.

**摘要**: 该研究统计了435例肿瘤的KRT7/KRT20表达模式，证实KRT7在卵巢癌、肺癌及尿路上皮癌中高表达，但在结直肠癌中多为阴性，强调其在确定肿瘤起源中的诊断价值。

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以上文献涵盖KRT7在正常组织表达、肿瘤分型及转移癌诊断中的应用，适合作为病理学研究的参考。如需具体期刊信息或页码，可进一步补充。

       

背景信息

KRT7 antibody is a diagnostic tool targeting cytokeratin 7 (KRT7), a member of the intermediate filament protein family expressed in epithelial cells. KRT7 plays a structural role in maintaining cellular integrity and mediating cell-cell interactions. As a type II keratin, it pairs with type I keratins (e.g., KRT19) to form heterodimers, contributing to tissue-specific cytoskeletal networks.

KRT7 is predominantly expressed in glandular and transitional epithelia, including tissues like the bile ducts, bladder, and respiratory tract. Its expression pattern makes it a valuable biomarker in pathology, particularly for distinguishing adenocarcinomas from squamous cell carcinomas or identifying tumors of epithelial origin. For example, KRT7 positivity helps differentiate cholangiocarcinoma (KRT7+) from hepatocellular carcinoma (KRT7−) or metastatic adenocarcinomas in the liver.

In diagnostic immunohistochemistry, KRT7 antibodies are often used alongside other markers (e.g., KRT20. TTF-1) to refine tumor classification. It is commonly expressed in carcinomas of the lung, breast, ovary, and urinary tract but absent in many colorectal, prostate, and hepatocellular malignancies. Additionally, KRT7 overexpression has been linked to tumor progression, metastasis, and drug resistance in certain cancers, making it a research focus in oncology.

Despite its utility, interpretation requires context, as KRT7 can occasionally be expressed in non-epithelial tumors (e.g., mesotheliomas) or benign conditions. Overall, the KRT7 antibody remains a cornerstone in diagnostic and research settings for epithelial tumor characterization.

       
KRT7抗体;KRT7;KRT7 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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