APLN抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12451(APLN Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12451(APLN Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of APLN Antibodies**

APLN (apelin) antibodies are immunological tools targeting apelin, a peptide hormone encoded by the *APLN* gene. Apelin plays critical roles in cardiovascular homeostasis, including vasodilation, angiogenesis, and fluid balance, by binding to its G protein-coupled receptor, APJ (APLNR). APLN antibodies are widely used in research to detect and quantify apelin expression in tissues or biological fluids via techniques like Western blot, immunohistochemistry, or ELISA.

Apelin's involvement in pathological conditions, such as heart failure, hypertension, and metabolic disorders, has driven interest in developing therapeutic antibodies. For instance, neutralizing APLN antibodies may modulate APJ signaling, offering potential in treating cardiovascular diseases or cancer, where apelin promotes tumor angiogenesis. Additionally, APLN antibodies aid in studying apelin's regulatory roles in obesity, diabetes, and inflammation.

Both monoclonal and polyclonal APLN antibodies are available, with specificity validated across species. Challenges remain in ensuring antibody selectivity due to apelin's multiple bioactive isoforms. Recent advances include humanized APLN antibodies for preclinical therapeutic exploration, though clinical applications are still emerging. Overall, APLN antibodies serve as vital reagents for unraveling apelin's physiological and pathological mechanisms, bridging translational research toward targeted therapies.