ZNF106抗体 新品

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12449(ZNF106 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12449(ZNF106 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The ZNF106 antibody is a research tool designed to detect and study the zinc finger protein 106 (ZNF106), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (KZFP) family. ZNF106. also known as ZFP91 or ZNF91 in some contexts, is encoded by the ZNF106 gene and is characterized by multiple C2H2-type zinc finger motifs, which facilitate DNA binding and protein-protein interactions. It plays roles in transcriptional regulation, chromatin remodeling, and cellular processes such as proliferation, differentiation, and apoptosis.

Antibodies targeting ZNF106 are used in applications like Western blotting, immunohistochemistry, and immunofluorescence to investigate its expression patterns, subcellular localization, and interactions. Studies suggest ZNF106 may act as a transcriptional repressor by recruiting chromatin-modifying complexes, such as histone deacetylases (HDACs), to regulate gene expression. Its involvement in neurodevelopment, immune responses, and cancer has drawn attention, though its precise mechanisms remain under exploration.

Aberrant ZNF106 expression has been linked to diseases, including certain cancers and Huntington’s disease, where dysregulation of zinc finger proteins may contribute to pathogenic pathways. However, research on ZNF106 is still evolving, with some studies reporting conflicting roles (e.g., tumor-suppressive vs. oncogenic effects), highlighting the need for further investigation. Commercial ZNF106 antibodies are typically validated for specificity in model organisms (e.g., human, mouse) and are critical for elucidating its biological and pathological significance.