BSN抗体 新品

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12447(BSN Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12447(BSN Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

**Background of BSN Antibody**

The BSN (Bassoon) antibody targets the Bassoon protein, a pivotal component of the presynaptic cytomatrix at the active zone (CAZ) in neuronal synapses. Bassoon, encoded by the *BSN* gene, is a large scaffolding protein predominantly expressed in the central nervous system. It plays a critical role in organizing synaptic vesicle release machinery, regulating neurotransmitter secretion, and maintaining synaptic integrity. Discovered in the late 1990s, Bassoon is essential for the structural and functional maturation of synapses, particularly in anchoring CAZ proteins and stabilizing presynaptic terminals during early neurodevelopment.

BSN antibodies are widely used in neuroscience research to investigate synaptic architecture, neurodevelopmental disorders, and neurodegenerative diseases. Abnormal Bassoon expression or dysfunction has been linked to conditions such as Alzheimer’s disease, autism spectrum disorders, and epilepsy. These antibodies enable visualization and quantification of Bassoon distribution via techniques like immunofluorescence, Western blotting, and immunohistochemistry. Recent studies also explore its role in synaptic plasticity and cognitive processes, highlighting its potential as a biomarker or therapeutic target. Despite advancements, the precise molecular mechanisms of Bassoon in disease pathogenesis remain an active area of investigation, underscoring the continued relevance of BSN antibodies in synaptic research.