ZFP30抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12439(ZFP30 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12439(ZFP30 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The ZFP30 antibody targets the zinc finger protein 30 (ZFP30), a member of the Krüppel-associated box (KRAB) domain-containing zinc finger protein (ZFP) family. ZFP30. encoded by the ZNF30 gene in humans, is a transcription factor characterized by multiple C2H2-type zinc finger motifs, which facilitate sequence-specific DNA binding. It is implicated in epigenetic regulation, particularly through interactions with chromatin-modifying complexes, and may play roles in gene silencing, cell differentiation, and development. Dysregulation of ZFP30 has been linked to certain cancers, including acute myeloid leukemia (AML), where its expression may influence oncogenic pathways or hematopoietic cell maturation.

ZFP30 antibodies are essential tools for studying its expression, localization, and molecular interactions. They are widely used in techniques like Western blotting, immunofluorescence, chromatin immunoprecipitation (ChIP), and immunohistochemistry to explore ZFP30's biological functions. Research using these antibodies has suggested ZFP30's involvement in modulating DNA methylation and transcriptional repression, potentially through recruitment of histone deacetylases (HDACs) or other co-repressors. Despite progress, ZFP30's precise mechanisms and full range of targets remain under investigation, highlighting the antibody's continued importance in elucidating its role in health and disease. Commercial ZFP30 antibodies are typically validated for specificity using knockout controls or siRNA-based approaches.