ZFAND2B抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue lysate, Primary antibody: P12438(ZFAND2B Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12438(ZFAND2B Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12438(ZFAND2B Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The ZFAND2B antibody is a tool used to detect the ZFAND2B protein, a member of the AN1-type zinc finger protein family. ZFAND2B (Zinc Finger AN1-Type Domain-Containing Protein 2B), also known as AIRAP-like or HSPC129. is encoded by the ZFAND2B gene located on human chromosome 2q31.2. This protein contains conserved AN1-type zinc finger domains, which are implicated in protein-protein interactions and ubiquitin-dependent processes. Studies suggest ZFAND2B plays a role in cellular stress responses, particularly in regulating proteostasis by interacting with the ubiquitin-proteasome system (UPS). It may assist in protein quality control, aiding the degradation of misfolded proteins under stress conditions like oxidative or endoplasmic reticulum stress.

ZFAND2B antibodies are widely utilized in research to explore the protein’s expression, localization, and function. They are employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to study ZFAND2B in various tissues and disease models. Dysregulation of ZFAND2B has been linked to cancer, neurodegenerative diseases, and metabolic disorders, making its antibody a valuable reagent for mechanistic studies. For instance, reduced ZFAND2B expression has been observed in certain cancers, correlating with altered proteasome activity and tumor progression. Commercially available ZFAND2B antibodies are typically validated for specificity and sensitivity, often targeting epitopes within its N-terminal or zinc finger domains. Ongoing research aims to clarify its precise molecular interactions and therapeutic potential in diseases involving proteostatic dysfunction.