WNT10B抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue lysate, Primary antibody: P12426(WNT10B Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12426(WNT10B Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

Wnt10b antibody is a research tool designed to detect and analyze the Wnt10b protein, a member of the Wnt family of signaling molecules. Wnt proteins are evolutionarily conserved glycoproteins critical for embryonic development, tissue homeostasis, and stem cell regulation. Wnt10b, specifically, plays a dual role in canonical (β-catenin-dependent) and non-canonical Wnt signaling pathways. It is implicated in adipogenesis inhibition, bone formation, and hair follicle development. Dysregulation of Wnt10b is linked to diseases such as obesity, osteoporosis, and cancers, including breast and colorectal cancer.

The antibody is widely used in immunohistochemistry, Western blotting, and flow cytometry to study Wnt10b expression patterns, localization, and interactions. Its applications extend to exploring molecular mechanisms in developmental biology, metabolic disorders, and tumorigenesis. For instance, elevated Wnt10b levels in certain cancers correlate with enhanced cell proliferation and metastasis, making it a potential therapeutic target. Conversely, reduced Wnt10b activity in adipose tissue may contribute to metabolic syndrome.

Commercial Wnt10b antibodies are typically raised in rabbits or mice against specific epitopes of the human or murine protein. Validation includes testing for cross-reactivity with other Wnt family members to ensure specificity. Despite its utility, challenges remain in standardizing detection across tissue types due to low endogenous protein levels and pathway complexity. Ongoing research aims to clarify its context-dependent roles and therapeutic potential in regenerative medicine and oncology.