WDR91抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12394(WDR91 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12394(WDR91 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

**Background of WDR91 Antibody**

WDR91 (WD Repeat-Containing Protein 91) is a conserved eukaryotic protein involved in regulating endosomal trafficking and autophagy. It contains WD40 repeats, which mediate protein-protein interactions, and functions as a component of the homotypic fusion and protein sorting (HOPS) complex. WDR91 is critical for endosome maturation, lysosomal degradation, and maintaining cellular homeostasis.

Antibodies targeting WDR91 are essential tools for studying its expression, localization, and molecular interactions. Research shows that WDR91 deficiency disrupts endosome-lysosome dynamics, leading to abnormal organelle enlargement and impaired autophagic flux, which are linked to neurodegenerative diseases and cancer. WDR91 also interacts with the mTORC1 pathway, suggesting roles in nutrient sensing and cell growth regulation.

WDR91 antibodies are widely used in techniques like Western blotting, immunofluorescence, and co-immunoprecipitation to explore its functional mechanisms in vitro and in vivo. These antibodies help identify WDR91's involvement in pathologies, such as tumor progression or neural dysfunction, and its potential as a therapeutic target. However, the precise molecular pathways regulated by WDR91 remain under investigation, emphasizing the need for high-specificity antibodies to advance understanding of its multifaceted roles in cellular physiology and disease.