BRWD1抗体

The BRWD1 (Bromodomain and WD Repeat-containing protein 1) antibody is a tool used to study the BRWD1 protein, which plays a role in epigenetic regulation and chromatin remodeling. BRWD1 contains tandem bromodomains that recognize acetylated lysine residues on histones, as well as WD40 repeats involved in protein-protein interactions. It is implicated in transcriptional regulation, cell cycle control, and DNA damage response pathways. Research links BRWD1 to hematopoiesis and cancer, particularly myeloid malignancies, where mutations or dysregulation may contribute to disease progression. Additionally, BRWD1 interacts with the ARID1A/BAF250A subunit of the SWI/SNF chromatin-remodeling complex, suggesting roles in modulating chromatin accessibility and gene expression. The BRWD1 antibody is widely used in techniques like Western blotting, immunofluorescence, and chromatin immunoprecipitation (ChIP) to investigate its expression, localization, and molecular interactions. Its application helps elucidate mechanisms underlying BRWD1-associated pathways in development, differentiation, and oncogenesis. Validated antibodies are critical for distinguishing BRWD1 from related family members (e.g., BRWD3) due to structural similarities. Ongoing studies aim to clarify its therapeutic potential in cancers and genetic disorders linked to chromatin dysregulation.