VAMP1抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Mouse brain tissue, Primary antibody: P12379(VAMP1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain tissue using P12379(VAMP1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12379(VAMP1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

**Background of VAMP1 Antibody**

Vesicle-associated membrane protein 1 (VAMP1), also known as synaptobrevin-1. is a member of the SNARE (soluble N-ethylmaleimide-sensitive factor attachment protein receptor) family. It plays a critical role in synaptic vesicle fusion and neurotransmitter release by mediating the docking and fusion of synaptic vesicles to the presynaptic membrane. VAMP1 is predominantly expressed in neurons and neuroendocrine cells, where it interacts with syntaxin and SNAP-25 to form the SNARE complex essential for exocytosis.

VAMP1 antibodies are immunological tools designed to detect and study the expression, localization, and function of VAMP1 in biological samples. These antibodies are widely used in techniques such as Western blotting, immunohistochemistry (IHC), immunofluorescence (IF), and immunoprecipitation (IP) to investigate synaptic transmission mechanisms, neuronal development, and disorders linked to synaptic dysfunction. For instance, altered VAMP1 levels or mutations have been implicated in neurological conditions like epilepsy, autism spectrum disorders, and certain neurodegenerative diseases.

Validated for specificity and sensitivity, VAMP1 antibodies often target conserved regions of the protein (e.g., the N- or C-terminal domains) and are tested across species, including human, mouse, and rat. Researchers rely on these antibodies to explore molecular pathways in both normal physiology and disease models, aiding in the development of therapeutic strategies targeting synaptic vesicle dynamics.