MPP6抗体

The MPP6 (Membrane Protein, Palmitoylated 6) antibody is a tool used to detect and study the MPP6 protein, a member of the membrane-associated guanylate kinase (MAGUK) family. MPP6 plays a critical role in maintaining cell polarity, synaptic organization, and cell-cell adhesion by acting as a scaffolding protein. It interacts with other MAGUK proteins, such as MPPs and DLGs, to stabilize multiprotein complexes at specialized membrane domains, including neuronal synapses and epithelial junctions. Structurally, MPP6 contains conserved PDZ, SH3. and guanylate kinase (GUK)-like domains, which mediate protein-protein interactions essential for its function. Research involving MPP6 antibodies has been pivotal in elucidating its localization, expression patterns, and involvement in cellular processes. Studies link MPP6 dysregulation to neurodevelopmental disorders and cancer progression, highlighting its biological significance. The antibody is commonly utilized in techniques like Western blotting, immunofluorescence, and immunohistochemistry to investigate MPP6's role in tissue-specific contexts or disease models. Recent advances also explore its potential as a biomarker or therapeutic target, particularly in neurological and oncological research. Commercial MPP6 antibodies are typically validated for specificity across human, mouse, and rat samples, enabling cross-species comparative studies.