UPP2抗体

The UPP2 antibody targets uridine phosphorylase 2 (UPP2), an enzyme involved in pyrimidine metabolism, catalyzing the reversible breakdown of uridine into uracil and ribose-1-phosphate. UPP2 plays a critical role in nucleotide salvage pathways, influencing cellular proliferation and tissue repair. It is highly expressed in certain cancers, including hepatocellular carcinoma and colorectal cancer, where it supports tumor growth by maintaining nucleotide pools for DNA synthesis. Research on UPP2 antibodies focuses on detecting UPP2 expression levels in pathological tissues, particularly to study its oncogenic role and potential as a diagnostic or prognostic biomarker. These antibodies are also utilized in mechanistic studies to explore UPP2's interaction with chemotherapeutic agents, as its activity may affect drug efficacy. Developed in hosts like rabbits or mice, UPP2 antibodies are validated for techniques such as Western blotting, immunohistochemistry, and ELISA. Their application extends to preclinical research aiming to inhibit UPP2 enzymatically, offering a therapeutic strategy to disrupt cancer cell survival. Overall, UPP2 antibodies serve as vital tools in both basic research and translational oncology.