HNRNPU抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-3: K562, MC3T3, Jurkat cell lysates, Primary antibody: P12371(HNRNPU Antibody) at dilution 1/600, Secondary antibody: Goat anti rabbit IgG at 1/5000 dilution, Exposure time: 5 minutes    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12371(HNRNPU Antibody) at dilution 1/50. (Original magnification: ×200)    

  
  

The heterogeneous nuclear ribonucleoprotein U (HNRNPU) antibody is a crucial tool in studying the functional roles of the HNRNPU protein, a member of the hnRNP family involved in RNA processing, chromatin remodeling, and genomic stability. HNRNPU binds to RNA and DNA, regulating mRNA splicing, transcriptional modulation, and maintaining nuclear architecture. It also plays a role in DNA repair and cell cycle control.

Antibodies targeting HNRNPU are widely used in molecular biology research to investigate its expression, localization, and interactions via techniques like Western blotting, immunofluorescence, and immunoprecipitation. Dysregulation of HNRNPU is linked to neurodevelopmental disorders, including autosomal dominant intellectual disability, epilepsy, and developmental delays. Mutations in the HNRNPU gene are associated with syndromes such as early infantile epileptic encephalopathy, making its antibody valuable for mechanistic studies and disease modeling.

Commercial HNRNPU antibodies are typically raised against specific epitopes (e.g., human HNRNPU fragments) and validated for specificity across species (human, mouse, rat). Researchers use these antibodies to explore HNRNPU's role in cellular stress responses, neuronal development, and cancer biology, where aberrant RNA processing contributes to tumor progression. Proper validation using knockout controls ensures reliable results in both diagnostic and experimental contexts.