CHRDL1抗体 新品

+ +

•  

   

     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: 293T cells, Human normal kidney tissue, Primary antibody: P12370(CHRDL1 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 3 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12370(CHRDL1 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The CHRDL1 (Chordin-like 1) antibody is a tool used to detect and study the CHRDL1 protein, a secreted glycoprotein belonging to the Chordin family. CHRDL1 functions as an antagonist of bone morphogenetic proteins (BMPs), particularly BMP4. by binding to them and preventing interactions with their receptors. This modulation of BMP signaling is critical in developmental processes, including neurogenesis, osteogenesis, and ocular development. In the eye, CHRDL1 is highly expressed in the retina and regulates aqueous humor dynamics, linking it to glaucoma pathogenesis. Dysregulation of CHRDL1 has also been implicated in cancer, where it may act as a tumor suppressor by inhibiting BMP-driven cell proliferation and metastasis.

CHRDL1 antibodies are widely used in research applications such as Western blotting, immunohistochemistry, and ELISA to quantify protein expression, map tissue distribution, or assess functional interactions in developmental and disease models. Structurally, CHRDL1 contains conserved cysteine-rich domains essential for BMP binding, and specific antibodies often target these epitopes. Recent studies highlight its potential as a biomarker in diseases like glioblastoma and age-related macular degeneration. Research using CHRDL1 antibodies continues to explore its therapeutic relevance, particularly in conditions involving BMP pathway dysregulation.