RAB2A抗体

+ +

•  

   

     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: Hela cell, Primary antibody: P12369(RAB2A Antibody) at dilution 1/350, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12369(RAB2A Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

•  

   

     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12369(RAB2A Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The RAB2A antibody is a crucial tool for studying the RAB2A protein, a member of the RAS-associated binding (RAB) GTPase family within the RAS superfamily. RAB GTPases are key regulators of intracellular vesicle trafficking, membrane dynamics, and organelle organization. Specifically, RAB2A localizes to the endoplasmic reticulum (ER)-Golgi interface and plays a role in mediating vesicular transport between these compartments, as well as autophagosome formation. It is implicated in diverse cellular processes, including secretion, autophagy, and Golgi homeostasis. Dysregulation of RAB2A has been linked to pathological conditions such as cancer progression, neurodegenerative disorders, and diabetes, making it a potential biomarker or therapeutic target.

The RAB2A antibody enables researchers to detect and quantify RAB2A expression in various biological samples using techniques like Western blotting, immunohistochemistry, and immunofluorescence. It is widely employed to investigate RAB2A’s subcellular localization, interaction partners, and functional mechanisms in both normal and disease contexts. Commercial RAB2A antibodies are typically generated using immunogenic peptides or recombinant protein fragments, with validation in specific applications to ensure specificity. However, users must verify cross-reactivity and optimal experimental conditions due to potential variability between antibody clones. Its utility extends to basic research on membrane trafficking pathways and translational studies exploring RAB2A’s role in disease pathogenesis.