TTBK2抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12342(TTBK2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12342(TTBK2 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

TTBK2 (Tau-tubulin kinase 2) is a serine/threonine kinase belonging to the casein kinase 1 (CK1) superfamily. It is primarily recognized for its role in phosphorylating tau and tubulin proteins, influencing microtubule dynamics and stability. TTBK2 is implicated in neurodegenerative diseases, particularly Alzheimer’s disease, where hyperphosphorylation of tau leads to neurofibrillary tangle formation, a hallmark of the condition. Beyond neurodegeneration, TTBK2 is essential for ciliogenesis, regulating the formation and maintenance of primary cilia—critical sensory organelles in cells. Mutations in the *TTBK2* gene are linked to spinocerebellar ataxia type 11 (SCA11), a rare autosomal dominant disorder characterized by progressive motor coordination deficits.

Antibodies targeting TTBK2 are vital tools for studying its expression, localization, and activity in biological systems. They enable detection of endogenous TTBK2 in tissues or cultured cells via techniques like Western blotting, immunohistochemistry, and immunofluorescence. These antibodies also aid in investigating post-translational modifications, kinase-substrate interactions, and pathological mechanisms in disease models. Commercial TTBK2 antibodies are typically raised against specific epitopes, such as the kinase domain or C-terminal regions, and are available in monoclonal or polyclonal formats. Validation includes testing for specificity using knockout controls or siRNA-mediated knockdown. Research utilizing TTBK2 antibodies continues to advance understanding of its dual roles in neurodegeneration and ciliary biology, offering potential therapeutic insights.