TTBK1抗体

The TTBK1 (Tau Tubulin Kinase 1) antibody is a tool used to study the TTBK1 protein, a serine/threonine kinase implicated in neurodegenerative diseases, particularly Alzheimer’s. TTBK1 phosphorylates tau, a microtubule-associated protein, at specific residues linked to neurofibrillary tangle formation—a hallmark of tauopathies. It also regulates ciliogenesis by modulating microtubule dynamics and centriolar satellite function. Structurally, TTBK1 contains a kinase domain and a unique C-terminal region that mediates substrate interactions. Research using TTBK1 antibodies focuses on detecting protein expression, localization, and phosphorylation activity in tissues or cell models. Studies highlight its dual role in neurodegeneration and ciliary biology, with elevated TTBK1 levels observed in Alzheimer’s brains. Antibodies against TTBK1 (monoclonal or polyclonal) are essential for Western blotting, immunohistochemistry, and functional assays to explore its pathological mechanisms or therapeutic targeting. Commercial antibodies are often validated for specificity to minimize cross-reactivity with related kinases like TTBK2.