TSPYL1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-2: Mouse brain tissue, Mouse heart tissue, Primary antibody: P12338(TSPYL1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    

  
  

The TSPYL1 (Testis-Specific Y-Encoded-Like Protein 1) antibody is a tool used to detect the TSPYL1 protein, a member of the TSPY-like gene family. TSPYL1. also known as CLL-associated antigen KW-5 or TSPX, is encoded on chromosome 6 and shares homology with the TSPY (testis-specific Y-encoded) proteins. Unlike TSPY, TSPYL1 is ubiquitously expressed and functions as a tumor suppressor. It regulates cell cycle progression by interacting with p53. modulating p21 expression, and inhibiting cyclin-dependent kinases (CDKs). Dysregulation of TSPYL1 is implicated in cancers, neurodegenerative disorders, and infertility.

TSPYL1 antibodies are widely used in research to study protein expression, localization, and function in both normal and pathological tissues. They are employed in techniques like Western blotting (WB), immunohistochemistry (IHC), and immunofluorescence (IF) to assess TSPYL1 levels in clinical samples or experimental models. Studies have linked reduced TSPYL1 expression to tumorigenesis in hepatocellular carcinoma, breast cancer, and gliomas, suggesting its role as a biomarker for prognosis or therapeutic targeting. Conversely, its overexpression is associated with neurodevelopmental defects. Commercial TSPYL1 antibodies are typically developed in rabbits or mice, targeting specific epitopes with validated specificity. Researchers rely on these antibodies to explore TSPYL1's regulatory networks and therapeutic potential in disease contexts.