TRPC5抗体

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     The image is immunohistochemistry of paraffin-embedded Human ovarian cancer tissue using P12332(TRPC5 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human colorectal cancer tissue using P12332(TRPC5 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

TRPC5 (Transient Receptor Potential Canonical 5) is a calcium-permeable non-selective cation channel belonging to the TRP channel superfamily. It plays critical roles in cellular processes such as signal transduction, cell proliferation, and apoptosis, and is implicated in neurological, renal, and cardiovascular functions. TRPC5 antibodies are essential tools for studying its expression, localization, and functional interactions. These antibodies are typically designed to recognize specific epitopes within TRPC5's structural domains, including its six transmembrane regions, intracellular N- and C-termini, or pore-forming loops.

Research using TRPC5 antibodies has revealed its involvement in pathological conditions. For instance, TRPC5 is upregulated in certain cancers, contributing to cell migration and invasion, and its dysregulation is linked to neurological disorders like epilepsy and anxiety. In the kidney, TRPC5 interacts with other channels to regulate ion transport, influencing blood pressure and renal disease progression. Antibodies against TRPC5 are widely employed in techniques such as Western blotting, immunohistochemistry, and immunofluorescence to validate protein expression in tissues or cultured cells. However, specificity validation is crucial due to potential cross-reactivity with homologous TRPC family members (e.g., TRPC1 or TRPC4) or splice variants. Recent studies also explore therapeutic applications, including targeting TRPC5 with monoclonal antibodies to modulate its activity in disease models. Overall, TRPC5 antibodies are pivotal in elucidating the channel’s physiological roles and its potential as a biomarker or therapeutic target.