TGM1抗体

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12322(TGM1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

**Background of TGM1 Antibody**

Transglutaminase 1 (TGM1), a calcium-dependent enzyme encoded by the *TGM1* gene, plays a critical role in epidermal differentiation and skin barrier formation. It catalyzes cross-linking of structural proteins, such as involucrin and loricrin, to form the cornified cell envelope, essential for maintaining skin integrity and hydration. Mutations in *TGM1* are linked to autosomal recessive congenital ichthyosis (ARCI), particularly lamellar ichthyosis, characterized by severe scaling and impaired barrier function.

TGM1 antibodies are immunological tools designed to detect and quantify TGM1 protein expression in research and diagnostics. These antibodies are pivotal in studying epidermal biology, elucidating mechanisms of skin disorders, and validating TGM1 deficiency in genetic studies. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to localize TGM1 in tissues or assess its expression levels.

Additionally, TGM1 antibodies hold therapeutic potential. In gene therapy research for ARCI, they help monitor TGM1 restoration in preclinical models. Recent advances also explore their use in enzyme replacement strategies or as targeting agents in drug delivery systems. However, challenges remain in ensuring antibody specificity and minimizing cross-reactivity with other transglutaminase isoforms (e.g., TGM2 or TGM3). Overall, TGM1 antibodies serve as indispensable reagents in dermatological research, bridging molecular insights to clinical applications.