TP53I11抗体

The TP53I11 (Tumor Protein p53 Inducible Protein 11) gene encodes a protein implicated in cellular stress responses, particularly under p53 pathway regulation. As a p53-inducible target, TP53I11 is activated during DNA damage, oxidative stress, or oncogenic signaling, contributing to cell cycle arrest, apoptosis, or metabolic adaptation. Its precise molecular function remains under investigation, but studies suggest roles in modulating intracellular redox balance and mitochondrial function. TP53I11 antibodies are essential tools for detecting the protein’s expression in research contexts, including cancer biology and stress response studies. These antibodies are typically used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to assess TP53I11 levels in tissues or cultured cells. Commercially available antibodies are often raised against specific epitopes, with validation data confirming specificity via knockout controls or siRNA knockdown. Dysregulation of TP53I11 has been observed in certain cancers, linking its expression to tumor suppression or progression depending on cellular context. Researchers utilize TP53I11 antibodies to explore its interaction networks, post-translational modifications, and subcellular localization, providing insights into its role in p53-mediated pathways and potential therapeutic applications. Recent studies also investigate its involvement in metabolic diseases and aging, broadening its relevance beyond oncology.