TNMD抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human fetal liver tissue lysate, Primary antibody: P12313(TNMD Antibody) at dilution 1/250, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 20 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12313(TNMD Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human esophagus cancer tissue using P12313(TNMD Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

**Background of TNMD Antibody**

Tenomodulin (TNMD), encoded by the *TNMD* gene, is a transmembrane glycoprotein predominantly expressed in tendons and related connective tissues. It belongs to the type II transmembrane protein family and shares structural homology with chondromodulin-I, playing a critical role in tendon development, maturation, and maintenance. TNMD is involved in regulating extracellular matrix (ECM) organization, collagen fibrillogenesis, and tenocyte proliferation, contributing to tendon strength and elasticity.

TNMD antibodies are immunological tools designed to detect and study TNMD expression and function. They are widely utilized in research to investigate tendon biology, degenerative tendon disorders (e.g., tendinopathy), and regenerative mechanisms. Studies have linked TNMD deficiency to impaired tendon healing and structural abnormalities, highlighting its therapeutic potential.

These antibodies are essential in techniques like immunohistochemistry, Western blotting, and flow cytometry, enabling visualization of TNMD localization in tissues and assessment of its expression levels under pathological or experimental conditions. Recent research also explores TNMD's role in stem cell differentiation and its interactions with growth factors (e.g., BMPs), further underscoring its relevance in musculoskeletal regeneration. TNMD antibodies thus serve as pivotal reagents in both basic research and translational studies targeting tendon repair and disease mechanisms.