TM7SF2抗体

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     The image is immunohistochemistry of paraffin-embedded Human cervical cancer tissue using P11516(NEK4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P11516(NEK4 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The TM7SF2 (Transmembrane 7 Superfamily Member 2) antibody is a tool used to study the function and expression of the TM7SF2 protein, a member of the 7-transmembrane superfamily. TM7SF2 is localized to the endoplasmic reticulum (ER) and plays a role in cholesterol biosynthesis by interacting with enzymes like HMG-CoA reductase. It has been implicated in regulating lipid metabolism and maintaining ER membrane structure. Studies suggest its involvement in cellular processes such as apoptosis, differentiation, and inflammatory responses. TM7SF2 is also linked to diseases, including metabolic disorders, neurodegenerative conditions, and cancers, where its dysregulation may affect cholesterol homeostasis or signaling pathways.

The antibody is commonly used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to detect TM7SF2 expression in tissues or cultured cells. Researchers utilize it to explore TM7SF2's role in pathologies, such as its potential as a biomarker in hepatocellular carcinoma or its association with altered cholesterol levels in neurological diseases. Additionally, TM7SF2 antibodies aid in studying molecular interactions, such as its partnership with lamin B receptor (LBR) in nuclear envelope formation. Validation of antibody specificity is critical due to structural similarities among transmembrane proteins. Overall, TM7SF2 antibodies are vital for elucidating its biological significance and therapeutic potential.