TRIM33抗体

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12288(TRIM33 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

TRIM33 (Tripartite Motif-containing 33), also known as TIF1γ or ectodermin, is a member of the TRIM protein family characterized by conserved RING, B-box, and coiled-coil domains. It functions as a transcriptional coregulator and E3 ubiquitin ligase, playing critical roles in TGF-β/Smad signaling, chromatin remodeling, and cellular differentiation. TRIM33 interacts with Smad proteins to modulate TGF-β-mediated responses, either enhancing or repressing target gene expression depending on cellular context. It also participates in DNA repair, hematopoiesis, and embryonic development by regulating histone modifications and epigenetic states.

TRIM33 antibodies are essential tools for studying its molecular mechanisms, localization, and expression levels in diseases. They are widely used in techniques like Western blotting, immunoprecipitation, and immunofluorescence to investigate TRIM33's involvement in cancer (e.g., suppressing tumor growth or metastasis), fibrosis, and immune disorders. Some antibodies target specific domains, such as the PHD/BROMO domain responsible for histone binding, enabling research into its chromatin-related functions. Validated TRIM33 antibodies often undergo knockout cell line testing to ensure specificity. Dysregulation of TRIM33 is linked to transcriptional instability and disease progression, making its study crucial for therapeutic targeting. Researchers rely on these antibodies to explore TRIM33's dual role as a tumor suppressor or oncogene, depending on tissue type and signaling environment.