TRIM24抗体

The TRIM24 antibody is a research tool used to detect and study TRIM24 (Tripartite Motif-containing protein 24), a member of the TRIM family of proteins characterized by their conserved RING, B-box, and coiled-coil domains. TRIM24 functions as an E3 ubiquitin ligase and transcriptional co-regulator, playing roles in chromatin remodeling, gene expression, and cellular differentiation. It interacts with nuclear receptors, such as the estrogen receptor (ER) and retinoic acid receptor (RAR), to modulate ligand-dependent transcriptional activity. TRIM24 is implicated in cancer progression, where it can act as an oncogene by promoting cell proliferation, suppressing apoptosis, or regulating DNA damage response pathways. However, its role varies contextually, showing tumor-suppressive activity in some malignancies. The TRIM24 antibody is widely utilized in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to assess protein expression levels, subcellular localization, and molecular interactions in both normal and diseased tissues. Its development and validation are critical for understanding TRIM24's involvement in diseases, including cancers, neurodegenerative disorders, and viral infections. Researchers also employ TRIM24 antibodies to explore its post-translational modifications and crosstalk with signaling pathways, aiding in the identification of therapeutic targets.