THAP3抗体

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     Gel: 12%SDS-PAGE, Lysate: 40 μg, Lane: 231 cells, Primary antibody: P12281(THAP3 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 30 seconds    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12281(THAP3 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The THAP3 antibody is a tool used to study the THAP domain-containing protein 3 (THAP3), a member of the THAP family of proteins characterized by a conserved THAP domain, a zinc-coordinating motif involved in DNA binding and protein interactions. THAP3 is implicated in transcriptional regulation, apoptosis, and cell cycle control. It functions as a nuclear protein, often acting in concert with other factors to modulate gene expression. Research suggests THAP3 may play roles in cancer progression, neurodevelopment, and metabolic pathways, though its precise mechanisms remain under investigation.

The antibody is primarily utilized in techniques like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to detect THAP3 expression levels and localization in tissues or cultured cells. It aids in exploring THAP3's interaction partners, post-translational modifications, and regulatory networks. Studies using THAP3 antibodies have revealed its overexpression in certain malignancies, linking it to tumor proliferation and metastasis. Additionally, its involvement in chromatin remodeling and epigenetic regulation highlights potential therapeutic targets.

Commercial THAP3 antibodies are typically raised in rabbits or mice, with validation data confirming specificity through knockdown/knockout controls. Researchers prioritize antibodies validated for cross-reactivity and batch consistency. Ongoing work aims to clarify THAP3's physiological roles and its biomarker potential in diseases, driving demand for reliable detection tools.