ELOA2抗体

The ELOA2 (Elongin A2) antibody is a research tool designed to detect and study the Elongin A2 protein, a component of the Elongin complex. This complex, primarily known for its role in transcriptional regulation, interacts with RNA polymerase II to facilitate transcriptional elongation. Elongin A2 shares structural homology with Elongin A1 but exhibits distinct expression patterns, particularly in certain tissues and developmental stages. It has garnered attention in cancer research due to potential links to tumorigenesis and cellular stress responses. The ELOA2 antibody is typically used in techniques like Western blotting, immunohistochemistry, and immunoprecipitation to investigate protein expression, localization, and interactions. Its development often involves immunizing hosts with peptide sequences unique to ELOA2 to ensure specificity. Validation includes testing on cell lines with confirmed ELOA2 expression and knockout controls. Researchers utilize this antibody to explore ELOA2's functional roles in gene regulation, DNA repair pathways, and its interplay with other elongation factors. Recent studies suggest its involvement in hypoxia-related pathways and cellular adaptation, making it relevant in understanding cancer progression and therapeutic resistance. Commercial ELOA2 antibodies usually provide datasheets detailing cross-reactivity, species specificity, and recommended experimental conditions.