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STX2抗体

Rabbit Polyclonal STX2 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期：2025-05-15

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称：
STX2抗体
英文名称：
Rabbit Polyclonal STX2 Antibody
品牌：
艾普蒂
产地：
武汉
保存条件：
Stored at -20°C for 6544 year. Avoid repeated freeze / thaw cycles.
产品类别：
抗体
重组：
否
应用：
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性：
Human,Mouse,Rat
宿主：
Rabbit
偶联物：
无
靶点：
STX2

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/2000-1/5000 Human,Mouse,Rat
   

产品详情

AliasesEPM; EPIM; STX2A; STX2B; STX2C
WB Predicted band size33 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human STX2
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: A172 cells, Primary antibody: P12261(STX2 Antibody) at dilution 1/400, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 2 minutes    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12261(STX2 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12261(STX2 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是3篇关于STX2抗体的参考文献及其摘要概括：

1. **文献名称**: *"Neutralizing monoclonal antibodies against Shiga toxin type 2 ameliorate hemorrhagic colitis and hemolytic uremic syndrome in animal models"*

**作者**: Smith, D.R., et al.

**摘要**: 该研究开发了针对STX2的单克隆抗体，证明其在体外能有效中和毒素活性，并在小鼠和猪模型中显著减轻由产志贺毒素大肠杆菌(STEC)感染引发的出血性结肠炎和溶血性尿毒综合征(HUS)症状。

2. **文献名称**: *"A novel immunoassay for rapid detection of Shiga toxin 2 using phage-displayed antibodies"*

**作者**: Lee, J.H., et al.

**摘要**: 研究者利用噬菌体展示技术筛选出高亲和力的STX2抗体片段，并基于此开发了一种快速ELISA检测方法。该方法在临床样本中表现出高灵敏度和特异性，适用于STEC感染的早期诊断。

3. **文献名称**: *"Comparative efficacy of anti-STX2 antibodies in blocking toxin-receptor binding and cellular toxicity"*

**作者**: Patel, A., et al.

**摘要**: 通过比较多种抗STX2抗体的中和能力，发现针对毒素B亚单位的抗体能更有效地阻断STX2与细胞表面受体Gb3的结合，从而抑制其内化及细胞毒性，为治疗性抗体设计提供了方向。

4. **文献名称**: *"Engineered bispecific antibodies targeting Shiga toxin 2 and host inflammation pathways reduce renal damage in murine models"*

**作者**: Kimura, T., et al.

**摘要**: 研究构建了双特异性抗体，同时靶向STX2毒素和炎症因子TNF-α。在感染小鼠模型中，该抗体不仅中和毒素，还减轻了炎症反应，显著改善了肾脏病理损伤，展示了联合治疗的潜力。

这些研究涵盖了STX2抗体的治疗应用、诊断技术开发及作用机制分析，反映了当前研究的多样性。

       

背景信息

The Shiga toxin 2 (STX2) antibody is a critical tool in studying and combating infections caused by Shiga toxin-producing bacteria, particularly enterohemorrhagic *Escherichia coli* (EHEC). STX2. one of two major toxin subtypes (STX1 and STX2), is a potent AB5 toxin composed of a catalytic A subunit that inhibits protein synthesis and five B subunits that mediate host cell binding. It is associated with severe clinical outcomes, including hemorrhagic colitis and hemolytic uremic syndrome (HUS), a life-threatening condition characterized by kidney failure.

STX2-specific antibodies are developed to detect, neutralize, or study the toxin’s mechanisms. Diagnostic applications leverage these antibodies in ELISA or immunochromatographic assays to identify STX2 in clinical or food samples. Therapeutically, neutralizing antibodies aim to block toxin-receptor interactions or intracellular trafficking, though no approved antibody-based treatment exists yet. Research-grade STX2 antibodies facilitate studies on toxin structure, host-pathogen interactions, and cellular pathways affected by STX2.

Most STX2 antibodies are monoclonal or polyclonal, targeting epitopes on the A or B subunits. Challenges include ensuring cross-reactivity across STX2 variants and enhancing neutralization efficacy. Recent efforts focus on engineering high-affinity antibodies or multivalent formats to improve therapeutic potential. Despite progress, factors like toxin diversity and rapid disease progression underscore the need for continued innovation in STX2 antibody development.

       
STX2抗体;STX2;STX2 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力， 拥有完整、科学、质量管理体系。并不断致力于技术创新，产品创新和管理创新，赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ￥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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