SMC5抗体

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     The image is immunohistochemistry of paraffin-embedded Human lung cancer tissue using P12217(SMC5 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SMC5 antibody is a research tool designed to detect and study the Structural Maintenance of Chromosomes 5 (SMC5) protein, a key component of the SMC5/6 complex. This complex, part of the larger SMC protein family, plays critical roles in maintaining genomic stability through DNA repair, sister chromatid cohesion, and chromosome dynamics during replication and mitosis. The SMC5/6 complex, composed of SMC5. SMC6. and non-SMC elements (NSE1-6), facilitates DNA damage response pathways, particularly homologous recombination repair and replication fork stabilization.

SMC5 antibodies are widely used in techniques like Western blotting, immunofluorescence, and immunoprecipitation to investigate protein expression, localization, and interactions in cellular models. Researchers employ these antibodies to explore SMC5’s involvement in resolving replication stress, preventing chromosomal aberrations, and safeguarding against tumorigenesis. Dysregulation of SMC5 is linked to cancer and developmental disorders, making it a focus in studies on genomic instability diseases.

Commercial SMC5 antibodies are typically raised against specific epitopes (e.g., human SMC5 N-terminal or coiled-coil regions) and validated for species reactivity (human, mouse, rat). Proper controls are essential due to potential cross-reactivity with other SMC proteins. Their applications span basic research on chromosome biology to translational studies targeting replication stress vulnerabilities in cancer therapy.