SLCO2B1抗体

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12207(SLCO2B1 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SLCO2B1 gene encodes the organic anion-transporting polypeptide 2B1 (OATP2B1), a membrane transporter protein belonging to the solute carrier (SLC) superfamily. Expressed in tissues such as the liver, intestine, placenta, and prostate, OATP2B1 facilitates the cellular uptake of various endogenous compounds (e.g., steroid hormones, prostaglandins) and xenobiotics, including statins, antihistamines, and anticancer drugs. Its role in drug absorption, distribution, and metabolism has made it a focus in pharmacokinetic studies, particularly regarding drug-drug interactions and interindividual variability in therapeutic responses.

SLCO2B1 antibodies are immunological tools developed to detect and quantify OATP2B1 expression in research and diagnostic contexts. These antibodies are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to study tissue-specific localization, protein regulation, and disease associations. For instance, altered OATP2B1 expression has been implicated in hormone-dependent cancers (e.g., prostate and breast cancer), where it may influence steroid hormone uptake and tumor progression. Additionally, SLCO2B1 antibodies help investigate transporter-mediated drug resistance or toxicity in preclinical models. Validation of these antibodies is critical, as nonspecific binding or cross-reactivity with other OATP isoforms can affect data reliability. Researchers prioritize antibodies with demonstrated specificity through knockout controls or siRNA-based silencing. Overall, SLCO2B1 antibodies serve as essential reagents for unraveling the transporter’s physiological roles and its implications in disease and drug therapy.