SLC9A3R2抗体

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12206(SLC9A3R2 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The SLC9A3R2 antibody is a research tool designed to detect and study the solute carrier family 9 member A3 regulator 2 (SLC9A3R2), a protein encoded by the *SLC9A3R2* gene in humans. This gene is part of the SLC9A regulatory factor family and shares homology with SLC9A3R1 (NHERF1), though its exact physiological role remains less characterized. SLC9A3R2 is implicated in regulating membrane-associated proteins, particularly sodium-hydrogen exchangers (NHEs), which are critical for maintaining cellular pH and ion homeostasis. It acts as a scaffold protein, facilitating interactions between transmembrane transporters, signaling molecules, and cytoskeletal components via its PDZ domains.

Antibodies targeting SLC9A3R2 are widely used in molecular and cellular biology research to investigate its expression, localization, and function in various tissues. They enable techniques such as Western blotting, immunohistochemistry, and immunofluorescence to assess protein levels and subcellular distribution. Studies have linked SLC9A3R2 to diverse biological processes, including renal function, cancer progression, and neurological disorders, though mechanistic insights are still evolving. For example, altered SLC9A3R2 expression has been observed in certain cancers, suggesting a potential role in tumorigenesis or metastasis. The antibody’s specificity and validation (e.g., knockout validation, peptide blocking) are critical to ensure reliable data. Ongoing research aims to clarify its interactions with signaling pathways (e.g., PDGFR, mTOR) and explore diagnostic or therapeutic applications.