SLC9A9抗体

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12205(SLC9A9 Antibody) at dilution 1/30. (Original magnification: ×200)    

  
  

The SLC9A9 antibody is a research tool designed to detect and study the solute carrier family 9 member A9 (SLC9A9) protein, a Na⁺/H⁺ exchanger (NHE) primarily localized to endosomal or lysosomal membranes. SLC9A9. encoded by the SLC9A9 gene, plays a critical role in regulating intracellular pH and ion homeostasis by mediating the exchange of sodium and hydrogen ions across membranes. This protein is implicated in vesicle trafficking, organelle acidification, and cellular processes like autophagy and signal transduction. Its expression is observed in various tissues, including the brain, gastrointestinal tract, and kidneys, with notable roles in neuronal and epithelial cell function.

Research using SLC9A9 antibodies has linked the protein to neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention-deficit/hyperactivity disorder (ADHD), as well as cancers and inflammatory bowel diseases. Antibodies targeting SLC9A9 are typically monoclonal or polyclonal and are validated for applications like Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF) to assess protein expression, subcellular localization, and interaction partners. These studies help elucidate SLC9A9's physiological mechanisms and its dysregulation in disease. Commercial SLC9A9 antibodies often undergo specificity testing using knockout cell lines or tissues to ensure reliability. Ongoing research aims to clarify its therapeutic potential, particularly in disorders involving disrupted ion transport or vesicular dynamics.