SLC7A9抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12203(SLC7A9 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using P12203(SLC7A9 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The SLC7A9 antibody is a research tool designed to detect and study the SLC7A9 protein, a subunit of the heterodimeric amino acid transporter responsible for cysteine and dibasic amino acid reabsorption in renal and intestinal epithelial cells. SLC7A9. encoded by the *SLC7A9* gene, pairs with SLC3A1 to form the b0.+AT transporter complex, localized to the apical membrane of proximal renal tubules. Mutations in *SLC7A9* are linked to cystinuria, an autosomal recessive disorder characterized by impaired renal reabsorption of cystine and dibasic amino acids, leading to recurrent kidney stone formation.

SLC7A9 antibodies are widely used in immunohistochemistry (IHC), western blotting (WB), and immunofluorescence (IF) to investigate protein expression, tissue distribution, and functional abnormalities in disease models. These antibodies aid in elucidating the molecular mechanisms of cystinuria, renal pathophysiology, and potential therapeutic targets. Commercial SLC7A9 antibodies are typically raised in hosts like rabbits or mice, targeting specific epitopes (e.g., C-terminal regions) with validation in knock-out controls or overexpression systems. Researchers rely on these antibodies to study transporter regulation, interaction partners, and mutations affecting protein stability or trafficking. Their application extends to diagnosing genetic variants and evaluating experimental treatments in preclinical studies.