SLC5A11抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12197(SLC5A11 Antibody) at dilution 1/35. (Original magnification: ×200)    

  
  

The SLC5A11 antibody is a tool used to detect and study the solute carrier family 5 member 11 (SLC5A11), a sodium-coupled transporter protein encoded by the *SLC5A11* gene. SLC5A11. also known as sodium-coupled monocarboxylate transporter 2 (SMCT2), facilitates the transport of monocarboxylates (e.g., lactate, pyruvate, and short-chain fatty acids) across cell membranes in a sodium-dependent manner. It is expressed in various tissues, including the brain, kidney, and intestine, and plays roles in metabolic homeostasis, nutrient absorption, and cellular energy balance.

Antibodies targeting SLC5A11 are essential for investigating its expression patterns, subcellular localization, and functional regulation in physiological and pathological contexts. They are widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence. Research involving SLC5A11 antibodies has shed light on its potential involvement in diseases such as cancer, neurological disorders, and metabolic syndromes, where altered monocarboxylate transport may impact cellular metabolism or signaling pathways.

These antibodies are typically validated for specificity and sensitivity, often generated in hosts like rabbits or mice using immunogenic peptide sequences. Their application helps unravel SLC5A11's interaction networks, tissue-specific roles, and therapeutic relevance, making them valuable in both basic research and preclinical studies targeting transporter-related pathologies.