SLC26A5抗体

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12187(SLC26A5 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The SLC26A5 gene encodes prestin, a membrane protein critical for auditory function in mammals. Prestin is predominantly expressed in outer hair cells (OHCs) of the cochlea, where it acts as a motor protein to drive somatic electromotility—a process essential for amplifying sound signals and enhancing hearing sensitivity. Antibodies targeting SLC26A5 are vital tools for studying prestin's localization, expression, and functional roles in auditory physiology. They are widely used in techniques like immunohistochemistry, Western blotting, and immunofluorescence to visualize prestin distribution in OHCs or assess protein levels in experimental models.

Research utilizing SLC26A5 antibodies has advanced our understanding of hearing mechanisms, including how prestin’s voltage-sensitive conformational changes contribute to cochlear amplification. These antibodies also aid in investigating hearing loss pathologies, such as mutations affecting prestin’s function or OHC degeneration. Additionally, they are employed in comparative studies across species to explore evolutionary adaptations in auditory systems.

Commercial SLC26A5 antibodies are typically raised against specific epitopes of the protein, often validated in knockout models to ensure specificity. Their applications extend to drug discovery, toxicology studies assessing ototoxic compounds, and diagnostic research targeting biomarkers for sensorineural hearing impairments. Overall, SLC26A5 antibodies serve as indispensable reagents in both basic and translational audiology research.