SLC25A38抗体

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12186(SLC25A38 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12186(SLC25A38 Antibody) at dilution 1/25. (Original magnification: ×200)    

  
  

The SLC25A38 antibody is a research tool designed to detect and study the SLC25A38 protein, a member of the solute carrier family 25 (SLC25) involved in mitochondrial transport processes. SLC25A38 is localized to the mitochondrial inner membrane and plays a critical role in amino acid metabolism, particularly in the transport of glycine and possibly serine, which are essential for heme biosynthesis. Mutations in the SLC25A38 gene are linked to congenital sideroblastic anemia, a rare blood disorder characterized by defective red blood cell formation due to impaired heme production.

Antibodies targeting SLC25A38 are widely used in molecular and cellular biology to investigate its expression, subcellular localization, and functional interactions. They enable techniques like Western blotting, immunofluorescence, and immunohistochemistry to visualize protein levels in tissues or cultured cells, aiding studies on mitochondrial dysfunction, erythropoiesis, and metabolic diseases. These antibodies are typically validated for specificity using knockout controls or siRNA-mediated gene silencing to ensure minimal cross-reactivity with related transporters.

Research applications extend to exploring SLC25A38's role in pathologies beyond anemia, including neurodegenerative disorders and cancer, where mitochondrial metabolism is dysregulated. The antibody's utility in both diagnostic and mechanistic studies underscores its importance in advancing understanding of mitochondrial biology and associated diseases.