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SGPL1抗体

Rabbit Polyclonal SGPL1 Antibody
询价 20μl 起订
50μl 起订
100μl 起订
湖北 更新日期:2025-05-15

湖北瑞和宁生物科技有限公司

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产品详情:

中文名称:
SGPL1抗体
英文名称:
Rabbit Polyclonal SGPL1 Antibody
品牌:
艾普蒂
产地:
武汉
保存条件:
Stored at -20°C for 6486 year. Avoid repeated freeze / thaw cycles.
产品类别:
抗体
重组:
应用:
WB: IHC-P: IHC-F: ICC/IF: IP:FC:ChIP: ELISA
种属反应性:
Human,Mouse,Rat
宿主:
Rabbit
偶联物:
靶点:
SGPL1

验证与应用

应用及物种
WB咨询技术 Human,Mouse,Rat
IF咨询技术 Human,Mouse,Rat
IHC1/25-1/100 Human,Mouse,Rat
ICC技术咨询 Human,Mouse,Rat
FCM咨询技术 Human,Mouse,Rat
Elisa1/1000-1/2000 Human,Mouse,Rat
   

产品详情

AliasesSPL; S1PL
WB Predicted band size64 kDa
Host/IsotypeRabbit IgG
Antibody TypePrimary antibody
StorageStore at 4°C short term. Aliquot and store at -20°C long term. Avoid freeze/thaw cycles.
Species ReactivityHuman, Mouse, Rat
ImmunogenSynthetic peptide of human SGPL1
FormulationPurified antibody in PBS with 0.05% sodium azide and 50% glycerol.

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       Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human placenta tissue, Primary antibody: P12164(SGPL1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 second    


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       The image is immunohistochemistry of paraffin-embedded Human breast cancer tissue using P12164(SGPL1 Antibody) at dilution 1/40. (Original magnification: ×200)    


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       The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12164(SGPL1 Antibody) at dilution 1/40. (Original magnification: ×200)    


           

参考文献

以下是关于SGPL1抗体的3篇参考文献示例(注:文献信息为示例,可能需根据实际研究调整):

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1. **文献名称**:*"SGPL1 regulates sphingolipid metabolism and endoplasmic reticulum stress in hepatic cells"*

**作者**:Chen Y, et al.

**摘要**:研究利用SGPL1特异性抗体通过Western blot和免疫荧光技术,揭示SGPL1在调节肝细胞鞘脂代谢及内质网应激中的作用,抗体验证了基因敲除模型中的蛋白表达缺失。

2. **文献名称**:*"A monoclonal antibody targeting SGPL1 for detection of lymphangiogenesis in tumors"*

**作者**:Martinez S, et al.

**摘要**:开发了一种高特异性抗人SGPL1单克隆抗体,应用于免疫组化和流式细胞术,证明SGPL1在肿瘤淋巴管生成中的表达上调,提示其作为生物标志物的潜力。

3. **文献名称**:*"SGPL1 deficiency disrupts adrenal steroidogenesis: Insights from immunohistochemical analysis"*

**作者**:Prasad R, et al.

**摘要**:通过SGPL1抗体对肾上腺组织进行免疫组化分析,发现SGPL1缺陷患者的酶表达缺失与类固醇合成障碍直接相关,为原发性肾上腺功能不全提供机制解释。

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如需真实文献,建议通过PubMed或Google Scholar搜索关键词“SGPL1 antibody”或“SGPL1 immunohistochemistry”获取最新研究。

       

背景信息

The SGPL1 (sphingosine-1-phosphate lyase 1) antibody is a tool used to study the enzyme encoded by the *SGPL1* gene, which plays a critical role in sphingolipid metabolism. SGPL1 catalyzes the irreversible cleavage of sphingosine-1-phosphate (S1P), a bioactive lipid involved in cellular processes like proliferation, apoptosis, and immune regulation. Dysregulation of SGPL1 is linked to diseases such as steroid-resistant nephrotic syndrome, primary adrenal insufficiency, and neurological disorders. The antibody detects SGPL1 protein expression in various tissues, aiding research into its function and distribution. It is widely used in techniques like Western blotting, immunohistochemistry, and immunofluorescence to explore SGPL1's role in health and disease. Studies also utilize the antibody to investigate therapeutic strategies targeting the S1P pathway in cancer, autoimmune conditions, and metabolic disorders.
       
SGPL1抗体;SGPL1;SGPL1 Antibody;

公司简介

湖北瑞和宁生物科技有限公司研究创新能力, 拥有完整、科学、质量管理体系。并不断致力于技术创新,产品创新和管理创新,赢得了国内外广大用户的信任。

成立日期 (2年)
注册资本 50万(元)
员工人数 1-10人
年营业额 ¥ 100万以内
经营模式 贸易,工厂,试剂,定制,服务
主营行业 中间体,化学试剂

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