SESN1抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-5: Lovo cells, hela cells, K562 cells, Raji cells, hepg2 cells, Primary antibody: P12161(SESN1 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 40 seconds    

  
  

**Background of SESN1 Antibody**

Sestrin1 (SESN1) is a stress-inducible protein belonging to the sestrin family, which includes SESN2 and SESN3. It plays a critical role in cellular responses to oxidative stress, DNA damage, and hypoxia. SESN1 acts as an antioxidant by regenerating peroxiredoxins, enzymes that neutralize reactive oxygen species (ROS), thereby protecting cells from oxidative damage. Additionally, SESN1 regulates metabolic homeostasis through modulation of the AMP-activated protein kinase (AMPK) and mechanistic target of rapamycin complex 1 (mTORC1) pathways, influencing processes like autophagy, cell proliferation, and energy metabolism.

Studies highlight SESN1's involvement in tumor suppression, as its expression is often downregulated in cancers, correlating with poor prognosis. It also contributes to lifespan regulation and age-related pathologies, including neurodegenerative and metabolic diseases. The SESN1 antibody is a vital tool for detecting and quantifying SESN1 protein levels in techniques like Western blotting, immunohistochemistry, and immunofluorescence. It enables researchers to explore SESN1's expression patterns, subcellular localization, and interactions under physiological or pathological conditions, such as cancer progression or oxidative stress models. Validated for specificity and sensitivity, SESN1 antibodies facilitate mechanistic insights into its roles in stress adaptation, metabolic regulation, and disease, making them essential for both basic and translational research.

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