SERINC4抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane: Human breast infiltrative duct tissue, Primary antibody: P12158(SERINC4 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

**Background of SERINC4 Antibody**

The SERINC (Serine Incorporator) family comprises transmembrane proteins involved in lipid metabolism and membrane-related processes, with SERINC4 being a less characterized member compared to its paralogs like SERINC5. SERINC4 is implicated in modulating membrane properties, potentially influencing viral infectivity, akin to SERINC5's role in restricting HIV-1 by incorporating into viral particles. However, its precise biological functions remain under investigation.

SERINC4 antibodies are essential tools for studying the protein's expression, localization, and interactions. These antibodies enable detection of SERINC4 in various applications, including Western blotting, immunohistochemistry (IHC), and immunofluorescence (IF), aiding research on its tissue distribution and subcellular dynamics. Studies suggest SERINC4 may have roles in cancer progression, neurodevelopment, or immune regulation, with altered expression observed in certain tumors and neurological disorders.

Commercial SERINC4 antibodies are typically raised against specific epitopes (e.g., N-terminal or C-terminal regions) and validated for specificity using knockout controls or siRNA-mediated silencing. Cross-reactivity with other SERINC family members (e.g., SERINC5) must be ruled out to ensure accuracy. Research utilizing these antibodies contributes to clarifying SERINC4's involvement in membrane biology, disease mechanisms, and potential therapeutic targeting. Ongoing efforts aim to define its interactions with pathogens, lipid pathways, and signaling networks, positioning SERINC4 as a protein of growing interest in cell biology and translational medicine.