SERINC2抗体

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     Gel: 8%SDS-PAGE, Lysate: 40 μg, Lane 1-6: K562 cells, NIH/3T3 cells, Jurkat cells, 293T cells, 231 cells, hepg2 cells, Primary antibody: P12156(SERINC2 Antibody) at dilution 1/200, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 1 minute    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human liver cancer tissue using P12156(SERINC2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

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     The image is immunohistochemistry of paraffin-embedded Human brain  tissue using P12156(SERINC2 Antibody) at dilution 1/20. (Original magnification: ×200)    

  
  

The SERINC2 (Serine Incorporator 2) antibody is a tool used to study the SERINC2 protein, a member of the SERINC family comprising five transmembrane proteins (SERINC1-5). SERINC2 is implicated in serine transport across cell membranes, though its full functional scope remains under investigation. It is broadly expressed in tissues, including the brain, immune cells, and reproductive organs, and is thought to influence lipid metabolism, membrane dynamics, and cellular signaling pathways.

Research using SERINC2 antibodies has highlighted its potential roles in neurodevelopment, cancer progression, and immune regulation. For instance, SERINC2 may modulate apoptosis and cell proliferation in tumors, with altered expression observed in cancers like gliomas and breast cancer. Additionally, SERINC proteins, including SERINC2. have been linked to antiviral defense, particularly in inhibiting HIV-1 infectivity by impairing viral fusion.

SERINC2 antibodies enable detection of protein expression, localization, and interaction partners via techniques like Western blot, immunohistochemistry, and immunoprecipitation. These studies help unravel SERINC2’s physiological and pathological mechanisms, including its crosstalk with other membrane proteins. Its conservation across species and tissue-specific expression patterns also suggest its importance in fundamental cellular processes. Ongoing research aims to clarify SERINC2’s precise biological functions and its potential as a therapeutic target or biomarker.