SERINC1抗体

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     The image is immunohistochemistry of paraffin-embedded Human prostate cancer tissue using P12155(SERINC1 Antibody) at dilution 1/40. (Original magnification: ×200)    

  
  

SERINC1 (Serine Incorporator 1) is a member of the SERINC family, comprising five transmembrane proteins (SERINC1-5) implicated in lipid metabolism, membrane biology, and cellular signaling. SERINC1 is a multi-pass membrane protein predominantly localized to the plasma membrane and intracellular vesicles. It is suggested to modulate lipid composition by facilitating serine incorporation into membranes, potentially influencing membrane fluidity, protein trafficking, and signal transduction. While SERINC5 is well-studied for its antiviral role in restricting HIV-1 infectivity, SERINC1's biological functions remain less defined but may intersect with cell death regulation, neuronal development, and tumor suppression.

SERINC1 antibodies are essential tools for detecting protein expression, localization, and interactions in research. They are widely used in techniques like Western blotting, immunofluorescence, and immunohistochemistry to explore SERINC1's roles in physiological and pathological contexts. Studies link SERINC1 dysregulation to cancer (e.g., reduced expression in gliomas or lung cancer), neurodevelopmental disorders, and immune responses. Validated antibodies often undergo specificity testing via knockout cell lines or siRNA-mediated silencing. Commercial SERINC1 antibodies are typically raised in rabbits or mice, targeting specific epitopes (e.g., N-terminal or cytoplasmic regions). Reliable antibodies are critical for elucidating SERINC1's molecular mechanisms and therapeutic potential in disease.